Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Triterpenoids are a large class of naturally occurring compounds found in many plants, including medicinal herbs traditionally used in dermatology. Scientific interest in triterpenoids for psoriasis arises from their known anti-inflammatory, antioxidant, and immunomodulatory properties, which are relevant to the pathogenesis of psoriasis—a chronic, immune-mediated skin disorder characterized by hyperproliferation of keratinocytes and inflammation. Several triterpenoids such as betulinic acid, oleanolic acid, and glycyrrhizin (from licorice) have demonstrated anti-psoriatic activity in preclinical studies. For example, glycyrrhizin has been shown in animal models and in vitro to reduce inflammation and suppress markers implicated in psoriasis, such as TNF-α and IL-17. Similarly, asiaticoside (from Centella asiatica) and madecassoside have shown promise in modulating skin inflammation and promoting wound healing. However, most of the available evidence is limited to laboratory and animal studies, with few well-designed clinical trials in humans. Some small clinical studies and case reports suggest benefits, but these are not definitive. Therefore, while there is a scientific rationale for the use of certain triterpenoids in psoriasis and some supportive preclinical evidence, robust human data are lacking, and thus the overall evidence supporting their use in psoriasis is currently low (rated 2/5).

More about Triterpenoid (unspecified)
More about Psoriasis

Other ingredients used for Psoriasis

Other health conditions supported by Triterpenoid (unspecified)

Products containing Triterpenoid (unspecified)