Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Sulforaphane, a naturally occurring isothiocyanate found in cruciferous vegetables (especially broccoli sprouts), has garnered attention for its antioxidant and anti-inflammatory properties. Scientific studies have suggested sulforaphane can activate the Nrf2 pathway, which upregulates cytoprotective and antioxidant genes while downregulating inflammatory mediators. Since oxidative stress and inflammation play key roles in the pathogenesis of psoriasis, researchers have explored sulforaphane as a potential adjunctive treatment.

A handful of preclinical studies and small pilot trials have investigated sulforaphane’s effects on psoriatic models. For example, a 2016 study published in "Oxidative Medicine and Cellular Longevity" found that sulforaphane reduced inflammatory cytokine expression and improved skin lesions in a mouse model of psoriasis. Early human trials are sparse, but one open-label pilot trial (2017, “Clinical, Cosmetic and Investigational Dermatology”) reported improvements in psoriatic plaques following oral supplementation with a broccoli sprout extract rich in sulforaphane.

However, robust clinical evidence is lacking. The existing studies are limited by small sample sizes, lack of placebo controls, and short durations. No large-scale randomized controlled trials have confirmed efficacy. Thus, while sulforaphane’s biochemical rationale is compelling and preliminary findings are promising, the current scientific evidence is low-to-moderate in quality and insufficient for strong clinical recommendations.

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