Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Piperine, an alkaloid found primarily in black pepper (Piper nigrum), has been explored for its potential therapeutic effects on psoriasis, primarily through preclinical studies. The interest in piperine for psoriasis is based on its anti-inflammatory and antioxidant properties, which are relevant given psoriasis is a chronic inflammatory skin disease. Animal and in vitro studies have shown that piperine can modulate immune responses, inhibit pro-inflammatory cytokines, and suppress keratinocyte proliferation—all of which are implicated in the pathogenesis of psoriasis. For example, a 2016 study published in the journal Cellular Physiology and Biochemistry reported that topical piperine ameliorated imiquimod-induced psoriasiform dermatitis in mice by inhibiting the STAT3 signaling pathway. However, there is a lack of clinical trials in humans directly assessing the efficacy or safety of piperine for psoriasis. Existing evidence remains preliminary and largely confined to laboratory models. There is no widespread traditional use of piperine or black pepper specifically for psoriasis, and its application is not part of standard dermatological practice. Thus, while there is some scientific basis for further investigation, the evidence supporting its use for psoriasis in humans is currently limited and insufficient to make clinical recommendations.

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