Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Phospholipids have some scientific basis for their use in supporting or treating psoriasis, though the evidence is limited and not robust. Phospholipids are essential components of cell membranes and play a role in maintaining skin barrier integrity. In psoriasis, the skin barrier is compromised, and inflammation is prominent. Some studies suggest that phospholipid-based topical formulations (such as liposomes or niosomes) can enhance the delivery and efficacy of anti-psoriatic drugs by improving their penetration and targeting inflamed skin areas. For example, research has shown that liposome-encapsulated corticosteroids or other anti-inflammatory agents may offer better therapeutic outcomes with fewer side effects compared to conventional formulations. Additionally, dietary phospholipids, such as phosphatidylcholine, have been investigated for their anti-inflammatory properties and potential to modulate immune responses, which are relevant to psoriasis pathophysiology. However, clinical evidence directly supporting oral or topical phospholipids as monotherapy for psoriasis is sparse, and most studies have focused on their role as drug delivery enhancers rather than as active therapeutics. In summary, there is some scientific rationale and preliminary research indicating a supportive role for phospholipids—mainly as delivery vehicles—in psoriasis management. However, the direct evidence for their efficacy as standalone treatments is weak, and more high-quality clinical trials are needed to establish their therapeutic value.

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