Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Niacinamide (vitamin B3) has been explored as a potential adjunctive therapy in psoriasis, primarily because of its roles in modulating inflammation, barrier function, and cellular energy metabolism. Scientific interest stems from niacinamide’s demonstrated anti-inflammatory properties: it inhibits the release of pro-inflammatory cytokines such as IL-1β, IL-6, and TNF-α, which are implicated in the pathogenesis of psoriasis. Additionally, niacinamide enhances epidermal barrier function by increasing the synthesis of ceramides and other lipids, which can be beneficial in skin conditions characterized by barrier disruption.

Despite these theoretical benefits and a few small-scale studies suggesting topical niacinamide may reduce erythema and scaling, the clinical evidence for its use in psoriasis remains limited and of low quality. Most available studies are either open-label, involve few participants, or assess niacinamide as part of a combination therapy (e.g., with corticosteroids or calcipotriol), making it difficult to isolate its specific effects. No large randomized controlled trials have definitively established its efficacy for plaque psoriasis. Current dermatological guidelines do not recommend niacinamide as a primary or standard therapy for psoriasis, but it may be considered as an adjunct in some cases due to its favorable safety profile.

In summary, while there is a plausible scientific rationale and some preliminary evidence, the overall support for niacinamide’s use in psoriasis is weak, meriting a low evidence rating. More robust clinical trials are needed to clarify its role.

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Nature's Sunshine B-Complex
Nature's Sunshine VitaWave