Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Mixed carotenoids, which include compounds such as beta-carotene, lutein, and lycopene, have been studied for their antioxidant and immunomodulatory properties, both of which are of interest in chronic inflammatory conditions such as psoriasis. Some scientific research suggests that oxidative stress plays a role in the pathogenesis of psoriasis, and carotenoids can quench free radicals and reduce oxidative stress. Small clinical studies and observational research have indicated that patients with psoriasis tend to have lower serum carotenoid levels compared to healthy controls, and that higher intake of carotenoid-rich foods may be associated with lower disease severity. Additionally, carotenoids can modulate immune function, potentially shifting the balance of pro- and anti-inflammatory cytokines. However, direct evidence from randomized controlled trials (RCTs) examining the efficacy of mixed carotenoid supplementation in treating or significantly improving psoriasis symptoms is limited and inconsistent. Most studies to date are either small, observational, or use carotenoids as part of a broader antioxidant or nutrient regimen, making it difficult to isolate their effect. Thus, while there is a plausible scientific rationale and some preliminary evidence supporting their use, the overall quality and quantity of evidence is not strong. Mixed carotenoids are generally considered safe, but more robust clinical trials are needed before recommending their routine use as a primary therapy for psoriasis.

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