Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Marine oils, particularly those rich in omega-3 polyunsaturated fatty acids (such as eicosapentaenoic acid [EPA] and docosahexaenoic acid [DHA]), have been studied for their potential benefits in inflammatory conditions, including psoriasis. Psoriasis is a chronic autoimmune skin disease characterized by inflammation and hyperproliferation of keratinocytes. Omega-3 fatty acids in marine oils are thought to exert anti-inflammatory effects by modulating the production of pro-inflammatory eicosanoids and cytokines involved in psoriasis pathogenesis.

Several randomized controlled trials and meta-analyses have evaluated the efficacy of oral marine oil supplementation (often in the form of fish oil) in improving psoriasis symptoms. Some studies report modest improvements in erythema, scaling, and thickness of psoriatic plaques, as well as reductions in Psoriasis Area and Severity Index (PASI) scores. However, results are mixed, with other trials showing minimal or no benefit compared to placebo. The variability in study design, dosage, and duration complicates interpretation.

Overall, while there is a scientific rationale and some limited clinical evidence supporting the use of marine oils in psoriasis, the magnitude of benefit is modest and not universally observed. Most guidelines do not recommend marine oil as a primary therapy, but it may be considered as an adjunct in certain cases. More rigorous and larger-scale studies are needed to confirm efficacy and establish optimal dosing.

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