Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Linoleic acid (LA), an essential polyunsaturated fatty acid found in many plant oils, has been investigated for its potential role in the management of psoriasis, a chronic inflammatory skin disease. Some scientific rationale exists for its use: LA is known to be a structural component of the skin barrier, helping maintain hydration and reduce transepidermal water loss. Psoriasis is characterized by impaired skin barrier function and inflammation, so theoretically, restoring lipid balance could be supportive. Furthermore, LA may modulate inflammatory pathways by influencing eicosanoid synthesis, possibly reducing pro-inflammatory mediators involved in psoriasis pathogenesis.

However, the clinical evidence for LA specifically (as opposed to general omega-6 or polyunsaturated fatty acid supplementation) is limited. A handful of small studies and older trials have explored topical and oral formulations containing LA, sometimes as part of complex mixtures, with modest improvements in symptoms like scaling and erythema. The effects appear to be mild and inconsistent, and LA is rarely used as a standalone therapy. Most clinical guidelines do not recommend LA as a primary or adjunctive treatment for psoriasis, and larger, well-controlled trials are lacking. Therefore, while there is some scientific rationale and limited preliminary evidence supporting its use, the overall strength of evidence is weak (rated 2 out of 5).

More about linoleic acid (LA)
More about Psoriasis

Other ingredients used for Psoriasis

Other health conditions supported by linoleic acid (LA)

Products containing linoleic acid (LA)

Nature's Sunshine Evening Primrose Oil