Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Flavones are a subclass of flavonoids found abundantly in various fruits, vegetables, and medicinal plants. Several in vitro and animal studies have suggested that flavones possess anti-inflammatory, antioxidant, and immune-modulatory properties, which are mechanisms relevant to the pathogenesis of psoriasis. Specific flavones such as apigenin, luteolin, and baicalein have shown potential in reducing the expression of pro-inflammatory cytokines (e.g., TNF-α, IL-17, IL-23) and inhibiting keratinocyte proliferation in experimental models. For instance, baicalein, derived from the root of Scutellaria baicalensis, has demonstrated psoriasis-ameliorating effects in murine models by modulating inflammatory pathways and reducing skin lesions.

However, the direct clinical evidence in humans is limited. Most data are preclinical or come from small pilot studies rather than large, high-quality randomized controlled trials. While some herbal remedies containing flavones have been used traditionally in Chinese medicine for skin disorders including psoriasis, the scientific validation in the context of psoriasis is primarily preliminary. As such, flavones are considered to have some scientific support for their use in psoriasis, but the strength of evidence is modest (rated 2/5), and further clinical research is needed to establish their efficacy and safety in human patients with psoriasis.

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