Synopsis

Source of validity: Scientific
Rating (out of 5): 2

D-alpha tocopherol, the natural form of vitamin E, is sometimes used as an adjunctive therapy for psoriasis due to its antioxidant and anti-inflammatory properties. The rationale is based on the idea that oxidative stress and inflammation play important roles in the pathogenesis of psoriasis. Several small clinical studies and case reports have explored the effect of vitamin E (including d-alpha tocopherol) on psoriasis symptoms. Some have reported modest improvements in erythema, scaling, and pruritus, particularly when vitamin E is used in combination with other antioxidants or topical therapies. For example, a 2009 randomized controlled trial found that a combination of vitamin E and evening primrose oil improved clinical symptoms in patients with mild psoriasis compared to placebo. However, standalone evidence for d-alpha tocopherol is limited and the effect size appears mild. Reviews and meta-analyses generally conclude that while vitamin E supplementation is safe, its efficacy for psoriasis is not robustly established, and larger, well-designed studies are needed. Therefore, the scientific evidence supporting the use of d-alpha tocopherol in psoriasis is weak to moderate, and its use is not considered standard therapy. Nonetheless, because of its low risk profile, it may be considered as an adjunct in patients seeking complementary approaches, but always with guidance from healthcare professionals.

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