Ceramides are lipid molecules that are essential components of the skin’s stratum corneum, the outermost layer of the epidermis. In psoriasis, a chronic inflammatory skin disease characterized by red, scaly plaques, the skin barrier is disrupted, and ceramide levels are commonly found to be reduced. This decrease contributes to increased transepidermal water loss and impaired barrier function, which can exacerbate symptoms such as dryness, irritation, and scaling.

Several studies have shown that topical products containing ceramides can help replenish the skin’s lipid barrier in both healthy and diseased skin, including in patients with psoriasis. These products may help reduce dryness, improve skin hydration, and support barrier repair. However, while ceramide-containing moisturizers are frequently recommended as adjunctive therapy for psoriasis (alongside anti-inflammatory and immunomodulatory treatments), the direct evidence for their efficacy specifically in treating the underlying disease process of psoriasis is limited. Most clinical evidence supports their role in symptom management and barrier restoration rather than addressing the immunological drivers of psoriasis itself.

In summary, the use of ceramides for psoriasis is scientifically grounded, particularly for improving skin barrier function and alleviating dryness, with a moderate level of supporting evidence. They are generally considered a supportive, rather than primary, treatment modality.