Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Beta glucans are naturally occurring polysaccharides found in the cell walls of cereals, bacteria, and fungi. Their use in psoriasis is supported primarily by preliminary scientific evidence, rather than strong traditional usage. Several preclinical studies and a small number of clinical trials have explored the immunomodulatory and anti-inflammatory properties of beta glucans. Beta glucans are known to modulate immune system activity, which is relevant to psoriasis, a chronic autoimmune skin disorder characterized by excessive inflammation and rapid skin cell turnover.

Research in animal models has shown that beta glucans can reduce inflammation and promote wound healing. Some small studies in humans suggest topical beta glucan formulations may reduce skin irritation and improve barrier function, which could be beneficial in managing psoriasis symptoms. For example, topical application of beta glucan in cream or gel form has demonstrated improvements in erythema, scaling, and itching in some cases, but these studies are typically small and not always specific to psoriasis.

There is limited evidence from oral supplementation studies in humans with psoriasis, and more high-quality, large-scale clinical trials are needed to confirm efficacy and safety. Overall, while beta glucans show potential due to their immunomodulatory effects, the current level of scientific evidence is modest, justifying a rating of 2 out of 5. They are not a standard or first-line therapy for psoriasis, but may be considered as a complementary option under medical supervision.

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