Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Baphicacanthus cusia (commonly known as Indigo naturalis or Qing Dai) has a long history of use in traditional Chinese medicine (TCM) for the management of various inflammatory skin disorders, including psoriasis. Historical TCM texts describe the external and internal use of Indigo naturalis preparations for alleviating symptoms such as redness, scaling, and itchiness associated with chronic skin conditions. The rationale in TCM is based on the herb’s perceived abilities to "clear heat" and "detoxify the blood," which are believed to underlie inflammatory skin eruptions like psoriasis.

While traditional use is well-documented, modern scientific evidence is emerging but still limited. Some small clinical studies and laboratory investigations have suggested that extracts of Baphicacanthus cusia can modulate inflammatory pathways, inhibit keratinocyte proliferation, and suppress cytokine expression relevant to psoriasis pathogenesis. However, high-quality, large-scale randomized controlled trials are lacking, and most evidence to date comes from small pilot studies or preclinical research. Topical formulations containing Indigo naturalis have shown some promise in reducing psoriatic lesions, but more rigorous studies are needed to confirm efficacy and safety.

In summary, the use of Baphicacanthus cusia for psoriasis is primarily supported by traditional practice, with preliminary but insufficient scientific evidence. This justifies a moderate evidence rating, reflecting the historical precedent and growing but not yet definitive clinical data.

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