Synopsis

Source of validity: Traditional
Rating (out of 5): 1

Arsenic has a long history of use in the treatment of psoriasis, primarily rooted in traditional and historical medical practices rather than modern scientific validation. In the 19th and early 20th centuries, arsenic compounds such as Fowler's solution (a potassium arsenite solution) were commonly prescribed for various skin conditions, including psoriasis. Early physicians observed some improvement in symptoms, which led to its widespread use before the advent of safer and more effective therapies. However, the mechanism by which arsenic might benefit psoriasis was not well understood, and its therapeutic window was narrow due to toxicity concerns. By the mid-20th century, the significant risks associated with arsenic—including carcinogenicity and systemic toxicity—led to its abandonment as a dermatological treatment. Modern clinical trials and systematic reviews do not support the efficacy or safety of arsenic for psoriasis. Today, arsenic is not recommended or used in evidence-based dermatological practice for this condition, and its historical use is primarily of academic interest. Thus, while arsenic has traditional roots in psoriasis care, its use is not supported by current scientific evidence, and it poses substantial health risks.

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