Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Aloe vera has been used traditionally for various skin conditions, including psoriasis, and there is some scientific evidence supporting its use. The evidence, however, is limited and not robust. Several small clinical trials and randomized controlled studies have investigated the topical application of aloe vera gel or cream for psoriasis. Some of these studies report modest improvements in scaling, erythema, and plaque thickness compared to placebo. For instance, a double-blind, placebo-controlled study published in the journal Phytotherapy Research (2010) found that aloe vera extract cream was more effective than placebo in reducing the severity of psoriasis plaques. Other studies have shown mixed or inconclusive results, often due to small sample sizes and methodological limitations.

The proposed mechanisms for aloe's effect include its anti-inflammatory, moisturizing, and wound-healing properties. Aloe vera contains compounds such as acemannan and various glycoproteins, which may help modulate inflammatory pathways involved in psoriasis. Despite these findings, major dermatological guidelines generally consider the evidence insufficient to recommend aloe vera as a primary treatment for psoriasis, but it may be used as an adjunct or complementary option for some patients seeking relief from symptoms like dryness and irritation.

In summary, while there is some scientific evidence for the topical use of aloe vera in mild to moderate psoriasis, the quality of the supporting studies is low, and the overall benefit appears to be modest. More rigorous research is needed to fully establish its efficacy and safety for this condition.

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