Evidence supporting the use of: Pepsin
For the health condition: Protein Digestion (poor)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Pepsin is a proteolytic enzyme naturally produced in the stomach, where it plays a central role in the digestion of dietary proteins. Its primary function is to break down complex protein molecules into smaller peptides, making them more accessible for further digestion and absorption in the small intestine. The use of pepsin supplements, often in combination with betaine hydrochloride (HCl), is scientifically justified for individuals who have low gastric acid production (hypochlorhydria) or certain digestive disorders leading to impaired protein digestion. Clinical studies and reviews have demonstrated that supplemental pepsin can improve protein digestion in patients with reduced gastric acidity, such as those with atrophic gastritis or after gastric surgery. Pepsin supplementation has also been utilized in cases where exogenous enzyme support is needed due to pancreatic insufficiency or other digestive enzyme deficiencies. However, the efficacy of pepsin supplements in individuals with normal digestive function is less clear, and unnecessary use is not generally recommended. Safety profiles are favorable when used as directed, although individuals with peptic ulcers or active gastritis should exercise caution. Overall, the scientific evidence supports the targeted use of pepsin supplementation for poor protein digestion associated with specific clinical conditions, with several studies illustrating improvements in digestive symptoms and protein assimilation.

More about pepsin
More about Protein Digestion (poor)

Other health conditions supported by pepsin

Acid Indigestion
Digestion (poor)
Indigestion
Protein Digestion (poor)