Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Papain is a proteolytic enzyme extracted from the papaya fruit (Carica papaya). Its use to support protein digestion is supported by both traditional practices and scientific research, though the strength of clinical evidence is moderate. Traditionally, papaya preparations have been used in various cultures to aid digestion and reduce symptoms related to indigestion. Scientifically, papain functions by breaking down large protein molecules into smaller peptides and amino acids, mimicking the activity of endogenous proteases in the gastrointestinal tract.

In vitro studies have demonstrated the enzymatic efficacy of papain in hydrolyzing dietary proteins. Animal studies and limited human trials suggest that papain supplementation can improve protein breakdown, especially in individuals with pancreatic insufficiency or other digestive disorders where endogenous enzyme production is compromised. For example, some small clinical studies have reported reduced symptoms of indigestion and improved protein absorption with papain-containing enzyme supplements. However, large-scale, well-designed clinical trials are lacking, and the overall quality of evidence is moderate.

Papain is generally considered safe at typical supplemental doses, though rare allergic reactions have been reported. It is used in a variety of digestive enzyme formulations marketed for people with poor protein digestion. In summary, while papain’s use for protein digestion is scientifically plausible and supported by moderate evidence, more robust human clinical trials are needed to firmly establish its efficacy in this context.

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Other ingredients used for Protein Digestion (poor)

Other health conditions supported by papain

Products containing papain

Nature's Sunshine Food Enzymes
Nature's Sunshine Sunshine Heroes Whole Food Papayazyme