Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Actinidin is a cysteine protease enzyme found primarily in kiwifruit (Actinidia deliciosa) and is known for its ability to break down protein molecules. The use of actinidin to support protein digestion is scientifically validated to a moderate degree. Several studies have demonstrated that actinidin can enhance the digestion of various dietary proteins, including those from meat, dairy, and legumes, under in vitro and in vivo conditions. For example, clinical and laboratory studies suggest that actinidin increases the rate of gastric protein hydrolysis and improves the bioavailability of amino acids from protein-rich foods. A randomized controlled trial found that consumption of kiwifruit with a protein-rich meal led to improved gastric comfort and faster gastric emptying compared to control groups, likely due to actinidin activity. In vitro studies have also shown that actinidin can supplement gastric and pancreatic enzymes, especially in individuals with sub-optimal digestive function. However, while the evidence is promising, most human studies have been small or preliminary in nature, and more robust clinical trials are needed to fully establish the benefits and optimal dosing of actinidin supplementation for protein digestion. In summary, there is moderate scientific support for the use of actinidin to aid protein digestion, particularly in those with poor digestive capacity.

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