The use of African Wild Potato (Hypoxis hemerocallidea) for prostatitis is primarily based on traditional medicine rather than robust scientific evidence. In Southern African traditional healing systems, the plant has been used for a variety of ailments, including urinary tract issues and symptoms related to the prostate, such as benign prostatic hyperplasia (BPH) and general inflammation. This usage is rooted in the plant's reputation as a tonic and its content of phytosterols, notably beta-sitosterol, which has been studied for prostate health in other contexts.

However, direct scientific studies specifically evaluating African Wild Potato for the treatment or management of prostatitis are lacking. Most of the available research has focused on its general anti-inflammatory, antioxidant, and immunomodulatory properties, or its use in BPH rather than prostatitis. The evidence for efficacy in prostatitis is thus anecdotal or extrapolated from its effects on prostate health more broadly. Systematic reviews and clinical trials supporting its use for prostatitis specifically are absent as of 2024. Therefore, while the plant is used traditionally for prostate-related complaints, its effectiveness for prostatitis remains unproven by modern clinical research.