Evidence supporting the use of: Sulphoraphane
For the body system: Prostate

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Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Sulforaphane, a bioactive compound found in cruciferous vegetables such as broccoli, has garnered scientific interest for its potential role in supporting prostate health. Several preclinical studies and a limited number of clinical trials suggest that sulforaphane may exert protective effects on the prostate, primarily through its antioxidant properties, modulation of detoxification enzymes, and anti-inflammatory activity. A key focus has been sulforaphane’s influence on pathways related to cancer development, particularly its ability to induce phase II detoxification enzymes and inhibit histone deacetylase, which may suppress the growth of prostate cancer cells in vitro and in animal models.

Human studies, though still limited in scope and size, have shown encouraging results. For example, a randomized controlled trial published in Cancer Prevention Research (2015) demonstrated that men consuming a broccoli-rich diet had favorable changes in gene expression associated with reduced prostate cancer risk. Another study found that sulforaphane supplementation reduced prostate-specific antigen (PSA) levels in men with recurrent prostate cancer, though the clinical significance remains uncertain and needs confirmation in larger studies.

Overall, while the mechanistic rationale is strong and early clinical data are promising, evidence is not yet robust enough to warrant a higher rating. More large-scale, well-designed human trials are needed to conclusively determine sulforaphane’s efficacy in supporting prostate health or preventing prostate disease.

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