Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Sterols, particularly plant sterols such as beta-sitosterol, have been studied for their effects on prostate health, especially in relation to benign prostatic hyperplasia (BPH), a common condition in aging men. Several randomized, placebo-controlled clinical trials and systematic reviews have suggested that beta-sitosterol can modestly improve urinary symptoms and flow measures associated with BPH. For example, a 1999 meta-analysis in "The Lancet" reviewed four randomized studies and concluded that beta-sitosterol improved urinary symptom scores and flow measures compared to placebo. The mechanism is thought to involve anti-inflammatory and anti-androgenic effects, as well as inhibiting 5-alpha-reductase, an enzyme involved in prostate enlargement. However, while the evidence demonstrates symptomatic relief, there is little indication that sterols reduce prostate size or affect long-term disease progression. Most guidelines consider sterols as a complementary option rather than a first-line treatment. The overall quality of evidence is moderate, with some limitations due to study size, duration, and heterogeneity. In summary, the use of sterols for supporting prostate health, particularly for BPH symptoms, is supported by scientific evidence, but the benefits are generally modest and should be considered alongside other therapeutic options.

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