Evidence supporting the use of: Isoflavone (unspecified)
For the body system: Prostate
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
Isoflavones, particularly those derived from soy (such as genistein and daidzein), have been studied for their potential effects on prostate health. Epidemiological data suggest that populations with high intake of soy foods tend to have lower rates of prostate cancer, and this has led to interest in isoflavones as a dietary supplement for prostate support. The presumed mechanism involves isoflavones' phytoestrogenic activity, which may modulate hormone-dependent growth of prostate tissue and exert weak estrogen-like effects that could counteract the actions of androgens in the prostate.
However, clinical trial evidence remains limited and mixed. Several small randomized controlled trials have investigated whether isoflavone supplementation can lower prostate-specific antigen (PSA) levels or reduce the risk of prostate cancer progression. While some studies have reported modest reductions in PSA or favorable effects on markers of prostate health, others have found no significant benefit. Systematic reviews and meta-analyses generally conclude that the evidence is insufficient to definitively support isoflavone supplementation for prostate health, with most studies being short-term and underpowered to detect significant clinical outcomes.
Overall, isoflavones are used for prostate support based on plausible biological mechanisms and some supportive epidemiological and clinical data, but robust clinical validation is lacking. Therefore, the evidence is rated as weak to moderate (2 out of 5).
Other ingredients that support Prostate
7-hydroxymatairesinol (HMR)beta-sitosterol
sesame
boron
broccoli
campesterol
turmeric
diallyl trisulfide (DATS)
DIM (diindolylmethane)
epigallocatechin gallate (EGCG)
flaxseed
gamma tocopherol
genistein
gokhru
green tea
HMR lignan
indole-3-carbinol
lignans
lycopene
mixed carotenoids
nettle
parsley
phytosterols
plant sterols
pollen
pomegranate
pumpkin
pygeum
quercetin
saw palmetto
secoisolariciresinol diglucoside
selenium
soybean
sterols
stigmasterol
tomato
vitamin D
watermelon
zinc
bee pollen
lingzhi
Equol (proprietary)
hydrangea
herbal blend (proprietary)
Apigenin
Alchornea
Alpha phytosterol
Allium tuberosum
Anti-aromatase
Brassica
berry
Brazil nut
Ba Ji Tian
Bee products
Borassus aethiopum
Chinese Mountain Ant
Cucurbita
Cynomorium
Cruciferous
Crinum latifolium
Decursin
Daidzein
Dwarf Nettle
Ellagic Acid
Fish
Fatty acids
Fireweed
Garlic
Isoflavones
Soy Protein
walnut
Other body systems supported by isoflavone (unspecified)
ArteriesBlood
Breasts
Estrogen
Female Reproductive System
Glandular System
Ovaries
Prostate
Reproductive System
Skeletal System (Bones)
Skin
Uterus
Vagina