Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Indole-3-carbinol (I3C) is a compound found in cruciferous vegetables such as broccoli, cabbage, and Brussels sprouts. Its use in supporting prostate health is primarily based on scientific investigation, though evidence is still preliminary. I3C is known to influence estrogen metabolism and promote the formation of less potent estrogen metabolites. This mechanism is relevant because estrogen metabolism and hormonal balance are implicated in the development and progression of prostate disorders, including benign prostatic hyperplasia (BPH) and prostate cancer. Several in vitro and animal studies have suggested that I3C and its derivative, diindolylmethane (DIM), may inhibit the growth of prostate cancer cells and modulate androgen receptor activity. Early-phase clinical studies have examined the safety and biochemical effects of I3C and DIM in men with prostate cancer, but robust clinical trials demonstrating clear benefits for prostate health in humans are lacking. As such, scientific interest exists and some mechanistic data support its use, but conclusive clinical evidence is limited. Therefore, while I3C is sometimes included in supplements targeting prostate health, its efficacy for this purpose is not well established.

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Nature's Sunshine Indole-3-Carbinol