Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Omega-3 fatty acids, particularly EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid), are scientifically validated to influence the prostaglandin system in the body. Prostaglandins are lipid compounds that play key roles in inflammation, immune function, and other physiological processes. Omega-3 fatty acids serve as precursors for a class of prostaglandins and related molecules (e.g., resolvins) that are generally less inflammatory compared to those produced from omega-6 fatty acids like arachidonic acid. Research demonstrates that increased dietary intake of omega-3s shifts prostaglandin synthesis towards these less inflammatory mediators, thereby modulating inflammation and immune responses. This effect underpins the use of omega-3s in managing conditions with an inflammatory component, such as rheumatoid arthritis and cardiovascular disease.

Multiple clinical trials and meta-analyses have shown that omega-3 supplementation can reduce markers of inflammation and improve symptoms in inflammatory diseases. The mechanistic basis is well established: omega-3s compete with omega-6s for incorporation into cell membranes and for enzymes that produce prostaglandins and leukotrienes, altering the balance towards anti-inflammatory eicosanoids. However, while the biochemical effects are clear, clinical outcomes vary by condition and individual, and omega-3s do not replace standard medical therapies. Overall, there is strong scientific evidence that omega-3 fatty acids support and modulate the prostaglandin system in the human body.

More about omega-3 fatty acids
More about Prostaglandins

Other ingredients that support Prostaglandins

Other body systems supported by omega-3 fatty acids

Products containing omega-3 fatty acids

Nature's Sunshine Flax Seed Oil (With Lignans)