Evidence supporting the use of: Evening primrose oil
For the body system: Prostaglandins

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Evening primrose oil (EPO) is often used as a dietary supplement because it is rich in gamma-linolenic acid (GLA), an omega-6 fatty acid that serves as a precursor to prostaglandins—hormone-like substances involved in inflammation and other physiological processes. The rationale for using EPO to support the "Prostaglandins body system" comes from its ability to increase GLA levels, potentially influencing the types and amounts of prostaglandins produced in the body.

There is some scientific evidence that EPO can increase GLA and affect prostaglandin synthesis, but the clinical relevance of this effect is less clear. Research has explored EPO in conditions thought to involve prostaglandin imbalances, such as eczema, rheumatoid arthritis, and premenstrual syndrome. However, results are mixed, with several systematic reviews and meta-analyses concluding that while EPO does change fatty acid profiles and possibly prostaglandin synthesis, its clinical benefits in these conditions are modest at best and often not statistically significant compared to placebo.

Overall, the use of EPO to support prostaglandin-related functions is grounded in biochemistry and has some scientific support, particularly in changing fatty acid and prostaglandin levels. However, robust clinical evidence supporting clear benefits for health outcomes remains limited, justifying a moderate evidence rating.

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