Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Calamari oil is derived from squid and is rich in omega-3 fatty acids, particularly docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). Scientific interest in calamari oil and similar marine oils stems from the role of omega-3 fatty acids as precursors for certain prostaglandins—lipid compounds that perform hormone-like functions in the body. Prostaglandins are synthesized from fatty acids and regulate processes such as inflammation, blood flow, and thrombosis. Specifically, EPA is a precursor for series-3 prostaglandins, which tend to be less inflammatory compared to those derived from arachidonic acid (an omega-6 fatty acid). Several studies have demonstrated that increased dietary intake of marine omega-3s (including those from calamari oil) can shift the balance of prostaglandin production toward less inflammatory types. While most research focuses on fish oil, calamari oil’s high DHA and EPA content suggests similar effects. There is moderate scientific evidence that omega-3 supplementation can modulate prostaglandin-mediated processes, particularly in relation to inflammation and cardiovascular health. However, direct studies on calamari oil and prostaglandin synthesis are fewer compared to fish oil, so the evidence is extrapolated. In summary, the use of calamari oil to support the prostaglandins body system is scientifically plausible and moderately supported by research on omega-3s, but direct clinical studies on calamari oil itself are limited.

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