Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitex agnus-castus, commonly known as chaste tree berry, has a long history of use in traditional medicine for various gynecological conditions, particularly those related to the menstrual cycle. The rationale for its use in supporting low progesterone primarily stems from its proposed dopaminergic effects on the pituitary gland. Vitex is thought to reduce prolactin secretion, which can help normalize the luteal phase of the menstrual cycle and potentially support endogenous progesterone production.

Several small clinical studies and systematic reviews suggest that Vitex may be effective in alleviating premenstrual syndrome (PMS) and some symptoms potentially related to luteal phase defects, which are often associated with insufficient progesterone. However, direct evidence that Vitex increases serum progesterone levels is limited and somewhat inconsistent. Most research focuses on its effects on PMS and premenstrual mastalgia, rather than on laboratory-confirmed low progesterone or infertility due to luteal phase defects.

Overall, while there is some scientific support for the use of Vitex in conditions that may overlap with low progesterone, such as PMS and certain menstrual irregularities, high-quality, large-scale studies directly linking Vitex to increased progesterone production are lacking. Thus, the evidence is moderate but not robust, and further research is warranted to clarify its mechanisms and efficacy in this specific context.

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