Relationship: Progesterone (low) and vitamin B6

Evidence supporting the use of: Vitamin B6
For the health condition: Progesterone (low)

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Source of validity: Traditional
Rating (out of 5): 2

Vitamin B6 (pyridoxine) is traditionally used to support or treat low progesterone levels, particularly in the context of premenstrual syndrome (PMS) and luteal phase defects. The rationale stems from early studies and anecdotal reports suggesting that vitamin B6 may help regulate hormonal balance, possibly by influencing neurotransmitter synthesis (such as serotonin and dopamine) and promoting the conversion of tryptophan to niacin, which may indirectly affect progesterone production. Some small clinical trials from the 1970s and 1980s reported improvements in PMS symptoms—some of which may be related to low progesterone—when women supplemented with vitamin B6. However, these studies often had methodological limitations, such as small sample sizes and lack of rigorous controls.

Current scientific evidence directly linking vitamin B6 supplementation with increased progesterone levels is limited and inconsistent. While B6 plays a role in overall hormone metabolism and may improve certain PMS symptoms, robust clinical trials confirming its specific effect on raising progesterone are lacking. Therefore, the use of vitamin B6 for this purpose is largely traditional, supported by limited and indirect scientific evidence. Most guidelines today recommend vitamin B6 for PMS symptom relief rather than as a direct treatment for low progesterone. As with any supplement, it should be used cautiously and under medical supervision, since high doses can cause neuropathy.

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Evidence supporting the use of: Vitamin B6
For the health condition: Progesterone (low)

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Health concerns

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Evidence supporting the use of: Vitamin B6For the health condition: Progesterone (low)

Table of Contents

Synopsis

Other ingredients used for Progesterone (low)

Other health conditions supported by vitamin B6

Products containing vitamin B6

Evidence supporting the use of: Vitamin B6
For the health condition: Progesterone (low)