Evidence supporting the use of: Chaste tree
For the health condition: Progesterone (low)

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Chaste tree (Vitex agnus-castus) is commonly used in herbal medicine for women's hormonal health, including the support of low progesterone levels. The scientific rationale comes from several clinical and preclinical studies suggesting that chaste tree extract may affect the hypothalamic-pituitary-gonadal axis. Specifically, chaste tree compounds (such as agnuside and casticin) are thought to influence the release of luteinizing hormone (LH), which in turn stimulates the corpus luteum to produce progesterone. This effect is most relevant in women with luteal phase defects, a common underlying cause of low progesterone and associated menstrual irregularities or premenstrual symptoms.

Clinical evidence is modest but promising. Several randomized controlled trials have shown that chaste tree extract can improve symptoms of premenstrual syndrome (PMS) and some menstrual irregularities, both of which can be linked to low progesterone states. However, direct measurement of progesterone levels in these studies is less common, and the exact mechanisms remain somewhat unclear. Traditional use, especially in European herbal medicine, also supports its use for menstrual and fertility concerns.

In summary, there is scientific evidence—though limited and not uniformly robust—that chaste tree may help support progesterone production via its effects on LH and the menstrual cycle. The evidence strength is moderate (rated 2), reflecting encouraging results but a need for more high-quality, targeted research.

More about chaste tree
More about Progesterone (low)