Evidence supporting the use of: Vitamin B6
For the body system: Progesterone

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B6 (pyridoxine) has been investigated for its potential role in supporting progesterone-related body systems, particularly in the context of premenstrual syndrome (PMS) and luteal phase support. Some clinical studies suggest that vitamin B6 supplementation may help alleviate PMS symptoms, which are believed to be partly due to fluctuations in progesterone and other hormones. The proposed mechanism is that vitamin B6 acts as a cofactor in the synthesis of neurotransmitters like serotonin and dopamine, which can be influenced by progesterone levels. Additionally, B6 may contribute to the proper metabolism of steroid hormones, including progesterone. However, the overall scientific evidence linking vitamin B6 directly to increased progesterone production or direct support of progesterone body systems is limited and somewhat inconsistent. While some small studies and clinical trials have shown modest benefit in the management of PMS symptoms (potentially related to progesterone), systematic reviews and larger meta-analyses have called for more robust, large-scale studies to confirm these effects. In summary, while there is a plausible biological rationale and some supportive evidence for vitamin B6's role in supporting the progesterone body system, especially in the context of PMS, the strength of evidence is moderate at best. The use of vitamin B6 for this purpose is justified by some scientific studies, but the effect size appears small and more research is needed for definitive conclusions.

More about vitamin B6
More about Progesterone

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