Synopsis

Source of validity: Scientific
Rating (out of 5): 5

Vitamin B9, particularly in its active form as methylfolate, is strongly supported by scientific evidence for use during pregnancy. Folate is essential for DNA synthesis, cell division, and fetal growth. Numerous large, well-controlled studies have demonstrated that adequate folate intake before conception and during early pregnancy significantly reduces the risk of neural tube defects (NTDs) such as spina bifida and anencephaly. This evidence forms the basis for global health recommendations: organizations like the Centers for Disease Control and Prevention (CDC), World Health Organization (WHO), and the American College of Obstetricians and Gynecologists (ACOG) all advise folic acid supplementation for women of childbearing age.

Methylfolate is the bioactive form of folate, and may be particularly beneficial for individuals with genetic variations (such as MTHFR polymorphisms) that impair the conversion of folic acid to its active form. Supplementation ensures that both mother and fetus have adequate folate levels to support normal development and reduce risks of certain birth defects. Beyond neural tube defects, sufficient folate may also contribute to lowering the risk of other congenital anomalies and pregnancy complications, though the strongest evidence is for NTD prevention. For these reasons, vitamin B9 (including methylfolate) is a cornerstone of prenatal supplementation and is supported by a robust body of scientific research.

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