Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Vitamin B12 (methylcobalamin) plays a crucial role in pregnancy, primarily due to its involvement in DNA synthesis, red blood cell formation, and neurological function. Scientific evidence strongly supports the need for adequate B12 intake during pregnancy, as deficiency can lead to serious complications for both mother and fetus. Low maternal B12 levels are associated with an increased risk of neural tube defects, preterm birth, low birth weight, and impaired cognitive development in the child. Research has shown that B12 supplementation, especially in populations at risk for deficiency (such as vegetarians, vegans, and individuals with malabsorption disorders), can help prevent these adverse outcomes.

The recommended dietary allowance (RDA) for pregnant women is higher than for non-pregnant women, reflecting increased physiological needs. Clinical guidelines from health organizations such as the World Health Organization (WHO) and the American College of Obstetricians and Gynecologists endorse ensuring adequate B12 intake during pregnancy. While routine supplementation is not universally recommended for all pregnant women with sufficient dietary intake, targeted supplementation is standard for those at risk of deficiency. Unlike some herbal supplements, B12’s use is not based on tradition but on well-established biochemical and clinical evidence. Most studies and official recommendations focus on B12 in general, not specifically methylcobalamin, but this is a bioactive form and is effective in supplementation.

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