Evidence supporting the use of: Choline
For the health condition: Pregnancy (herbs and supplements for)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Choline is an essential nutrient that plays a critical role in fetal development during pregnancy, with strong scientific support for its use as a prenatal supplement. Choline is vital for the synthesis of cell membranes, neurotransmitter production (notably acetylcholine), and methylation processes. Studies have shown that adequate maternal choline intake supports normal brain development in the fetus and may reduce the risk of neural tube defects and other birth complications. Research, including randomized controlled trials, has indicated that higher choline intake during pregnancy can improve cognitive function in offspring and may offer protection against certain stressors and toxins. The adequate intake (AI) level for pregnant women is set at 450 mg per day by the Institute of Medicine. However, surveys indicate that most pregnant women consume less than recommended amounts, leading to concerns about widespread choline insufficiency. Major health organizations, including the American Medical Association and the American Academy of Pediatrics, recognize the importance of choline in prenatal nutrition. While choline is present in foods like eggs, liver, and some meats, supplementation is often recommended for those who may not meet dietary requirements. Overall, the scientific evidence strongly supports the use of choline to support pregnancy, particularly for fetal brain development and prevention of certain birth defects.

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