Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Pregnenolone is a neurosteroid that has been investigated for its potential role in treating Post Traumatic Stress Disorder (PTSD), with some scientific evidence supporting its use. Pregnenolone is a precursor to various steroid hormones, including progesterone, and has demonstrated neuromodulatory effects in the central nervous system. Research suggests that abnormalities in neurosteroid levels, including pregnenolone, may be associated with PTSD symptoms, particularly in the domains of anxiety, cognition, and stress response.

Several small-scale clinical trials and preclinical studies have explored pregnenolone’s efficacy. For example, a randomized, placebo-controlled pilot study published in "Neuropsychopharmacology" (2017) found that adjunctive pregnenolone significantly improved cognitive symptoms in patients with PTSD compared to placebo. Other studies have demonstrated that pregnenolone can enhance GABAergic and glutamatergic neurotransmission, which are systems implicated in PTSD pathology. Additionally, animal models have shown that pregnenolone administration can reduce anxiety-like behaviors and enhance stress resilience.

However, the evidence base is still limited, with relatively few clinical trials, small sample sizes, and a lack of long-term data. More robust, large-scale studies are required to confirm pregnenolone’s efficacy and safety in PTSD. Thus, while there is preliminary scientific support for its use, the overall strength of evidence remains modest at this time.

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