Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Melatonin, a hormone primarily involved in regulating the sleep-wake cycle, has garnered scientific interest as a potential adjunctive treatment for Post Traumatic Stress Disorder (PTSD). PTSD is frequently associated with sleep disturbances, including insomnia and nightmares, which can exacerbate overall symptom severity. Melatonin’s role in improving sleep quality provides a plausible mechanism for its therapeutic use in PTSD patients. Several small randomized controlled trials and animal studies suggest that melatonin supplementation may reduce sleep onset latency, improve sleep quality, and even decrease the frequency and severity of nightmares in individuals with PTSD. Additionally, melatonin has demonstrated some neuroprotective and anti-inflammatory properties in preclinical models, which could theoretically benefit PTSD patients by modulating the stress response and neuroendocrine function.

However, the evidence base remains limited, with relatively few well-powered human trials directly addressing melatonin’s impact on core PTSD symptoms beyond sleep regulation. Most studies focus on sleep-related outcomes rather than broader PTSD symptomatology, and results are mixed regarding its effectiveness for daytime anxiety, flashbacks, or mood disturbances. As such, while melatonin is sometimes used clinically to support sleep in PTSD patients, its use is not yet fully endorsed by major psychiatric guidelines for comprehensive PTSD management. More robust, large-scale clinical trials are needed to clarify its efficacy and optimal usage in this context.

More about melatonin
More about Post Traumatic Stress Disorder

Other ingredients used for Post Traumatic Stress Disorder

Other health conditions supported by melatonin

Products containing melatonin

Nature's Sunshine Melatonin Extra