Evidence supporting the use of: Docosahexaenoic Acid
For the health condition: Post Traumatic Stress Disorder

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Docosahexaenoic acid (DHA) is an omega-3 fatty acid that has been investigated for its effects on various neuropsychiatric conditions, including Post-Traumatic Stress Disorder (PTSD). The rationale for using DHA in PTSD is rooted in its essential role in brain structure, function, and neuroinflammation modulation. Some preclinical studies and small clinical trials have suggested that omega-3 fatty acids, including DHA, may reduce the risk of developing PTSD or alleviate its symptoms, possibly through anti-inflammatory and neuroprotective mechanisms. However, the scientific evidence remains limited and inconsistent. A few randomized controlled trials (RCTs) have explored DHA (often in combination with eicosapentaenoic acid, EPA) supplementation in individuals exposed to trauma or diagnosed with PTSD. Some have reported modest improvements in symptoms, while others have found no significant benefit compared to placebo. Systematic reviews and meta-analyses typically conclude that, although biologically plausible, the current evidence base is insufficient to recommend DHA as a standard treatment or preventive intervention for PTSD. Most guidelines do not include DHA as a validated therapy for PTSD due to the low quality and heterogeneity of available studies. Therefore, while there is some scientific investigation into DHA for PTSD, the evidence supporting its use is weak and preliminary.

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Products containing Docosahexaenoic Acid

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