False Unicorn Root (Chamaelirium luteum) has been traditionally used in North American herbal medicine, particularly by Native American tribes and later by 19th-century eclectic physicians, to support women's reproductive health. This included its application for symptoms associated with post-partum weakness, such as fatigue, pelvic pain, and uterine prolapse. Herbalists historically believed that False Unicorn Root could "tone" the uterus, restore vitality, and address what was termed "female weakness" after childbirth.

However, scientific validation of these uses is extremely limited. There are no well-controlled clinical trials or pharmacological studies directly supporting its efficacy or safety for post-partum weakness. Most references in herbal literature are anecdotal or based on traditional frameworks rather than empirical data. Modern phytochemical analyses have identified steroidal saponins in the root, which are speculated to have hormonal or tonic effects, but these claims remain unsubstantiated in the context of human post-partum recovery.

In summary, the use of False Unicorn Root for post-partum weakness is primarily justified by tradition, with a low level of evidence (rated as 1), and lacks rigorous scientific support.