Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B6 (pyridoxine hydrochloride) is sometimes used to support or treat PMS Type S (the "S" refers to symptoms dominated by swelling or bloating, often linked to water retention). The rationale for its use is based on B6’s role in neurotransmitter synthesis, particularly serotonin and dopamine, as well as its involvement in modulating hormonal activity and possibly influencing aldosterone-mediated fluid retention.

Several clinical studies from the 1970s to the early 2000s have evaluated B6 for general PMS symptoms, with mixed results. Some small trials suggested modest benefit for symptoms such as mood changes and bloating, but methodological limitations (small sample sizes, lack of blinding, variable diagnostic criteria) limit their reliability. One systematic review (Wyatt et al., 1999, BMJ) concluded that there was limited and inconsistent evidence in support of B6 for PMS, with some studies showing mild to moderate improvement in overall symptoms, but not specifically for bloating or water retention.

Subsequent reviews (e.g., Dickerson et al., 2003, J Am Pharm Assoc) echoed these findings, stating that while B6 may help with some PMS symptoms, the evidence for its effectiveness in treating PMS Type S specifically is weak. Doses above 100 mg/day are not recommended due to the risk of neuropathy. Overall, while there is some scientific investigation, the quality and consistency of evidence for B6’s benefit in PMS Type S is low.

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