Evidence supporting the use of: Vitamin B6 (pyridoxamine HCl)
For the health condition: PMS Type S

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B6 (specifically as pyridoxamine HCl or the more common pyridoxine) has been investigated for its role in alleviating symptoms of premenstrual syndrome (PMS), including PMS Type S, which is characterized by symptoms related to serotonin imbalance such as mood swings, irritability, anxiety, and depression. The rationale for its use is based on the role of vitamin B6 as a cofactor in the synthesis of neurotransmitters, including serotonin and dopamine. Several clinical trials and meta-analyses have evaluated the efficacy of vitamin B6 supplementation in PMS. A 1999 meta-analysis published in the British Journal of Obstetrics and Gynaecology found that vitamin B6 was more effective than placebo in relieving premenstrual symptoms, particularly mood-related symptoms, though the studies were generally small and of variable quality. Dosages used in studies typically ranged from 50 to 100 mg per day. However, the overall quality of evidence is moderate at best. More recent systematic reviews, such as one in the Cochrane Database (2009), conclude that while there may be some benefit, the data are insufficient and not robust enough to make strong recommendations. The mechanism—supporting serotonin synthesis—remains plausible, but definitive clinical validation is lacking. Some guidelines acknowledge B6 as a potential option, but emphasize that more rigorous studies are needed. Therefore, while there is some scientific basis for its use in PMS Type S, the strength of evidence is modest.

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