Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Diindolylmethane (DIM) is a compound formed in the body during the digestion of indole-3-carbinol, which is found in cruciferous vegetables like broccoli and Brussels sprouts. Its primary relevance to PMS Type S (PMS with symptoms dominated by swelling, bloating, and breast tenderness, often related to estrogen excess or imbalance) is based on DIM’s ability to modulate estrogen metabolism. Specifically, DIM promotes the conversion of estradiol (a potent form of estrogen) into less active metabolites, which may help balance estrogen activity in the body. There is limited but growing scientific evidence to support the use of DIM for symptoms related to estrogen dominance, including those seen in PMS Type S. Several small clinical trials and animal studies have shown that DIM supplementation can shift estrogen metabolism toward a more favorable profile, lowering the levels of the more active (and potentially problematic) estrogens. However, direct clinical studies on DIM specifically for PMS symptoms remain sparse, and most evidence comes from extrapolation of its effects on estrogen metabolism or from studies in conditions like cyclical mastalgia (breast pain) or hormone-sensitive cancers. In summary, while there is a plausible scientific rationale and some preliminary evidence to support the use of DIM for PMS Type S, well-controlled clinical trials are lacking, and evidence strength is currently moderate to low. More research is needed before DIM can be confidently recommended as a primary treatment for PMS Type S.

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