Evidence supporting the use of: Vitamin B6 (pyridoxamine HCl)
For the health condition: PMS Type P

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B6 (pyridoxamine HCl) has been studied as a treatment for premenstrual syndrome (PMS), including PMS Type P (predominantly characterized by pain and physical symptoms). Scientific evidence suggests that vitamin B6 may have a modest benefit in alleviating certain PMS symptoms, particularly mood-related and physical complaints such as breast tenderness and bloating. Several randomized controlled trials and meta-analyses have investigated the effectiveness of vitamin B6, generally at doses ranging from 50 mg to 100 mg per day. A 1999 meta-analysis published in the British Journal of Obstetrics and Gynaecology concluded that vitamin B6 is more effective than placebo for treating PMS, though the effect size was moderate, and study quality varied. The mechanism is thought to involve vitamin B6’s role in neurotransmitter synthesis (particularly serotonin and dopamine), which may influence mood and pain perception. However, the overall quality of evidence is limited by small sample sizes, inconsistent methodologies, and potential publication bias. Some more recent systematic reviews have called for higher-quality, larger-scale studies, noting that while there may be a benefit, it is not robustly supported. Safety also becomes a concern at higher doses, as prolonged use of vitamin B6 above 100 mg/day can result in neuropathy. Therefore, while there is scientific validation for the use of vitamin B6 in PMS Type P, the strength of evidence is moderate at best.

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