Evidence supporting the use of: Vitamin B6
For the health condition: PMS Type H

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin B6 (pyridoxine) is commonly used to support or treat symptoms of premenstrual syndrome (PMS), including PMS Type H (which is characterized by "hyperhydration" symptoms such as bloating, breast tenderness, and swelling). The scientific rationale is based on vitamin B6's role in neurotransmitter synthesis, particularly serotonin and dopamine, which can influence mood and fluid regulation. Several clinical trials and systematic reviews have evaluated the efficacy of vitamin B6 in relieving PMS symptoms. A 1999 meta-analysis published in the British Medical Journal found that vitamin B6 was more effective than placebo in reducing overall PMS symptoms, though the quality of evidence was moderate and effect sizes were modest. More recent studies have also reported beneficial effects, particularly for mood-related symptoms, but the evidence for relief of physical symptoms such as those associated with Type H PMS is less robust.

Despite some methodological limitations in the available studies (e.g., small sample sizes, varying dosages, and differing symptom classifications), the overall evidence suggests that vitamin B6 may provide mild-to-moderate relief for PMS symptoms, including those of hyperhydration. Doses between 50-100 mg/day are most commonly used in studies, as higher doses carry a risk of neuropathy with prolonged use. In summary, there is moderate scientific support for the use of vitamin B6 in PMS, with some validation for its use in PMS Type H, though further large-scale, high-quality trials are warranted to confirm its efficacy and optimal dosing for this specific subtype.

More about vitamin B6
More about PMS Type H

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