Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B6 (pyridoxine hydrochloride) is used to support or treat premenstrual syndrome (PMS), including what is sometimes referred to as "PMS Type C" (characterized by carbohydrate cravings, headaches, fatigue, and increased appetite). The rationale is based on B6’s role in neurotransmitter synthesis, particularly serotonin and dopamine, which may be dysregulated during the luteal phase of the menstrual cycle and contribute to PMS symptoms. Several clinical studies and randomized controlled trials have evaluated the effect of B6 on PMS symptoms with mixed but generally modestly positive results. A 1999 systematic review (Obstet Gynecol. 1999;94:779-786) concluded that B6 may be beneficial for overall PMS symptoms, but the evidence was limited by small sample sizes and variable quality. More recent meta-analyses suggest a small but statistically significant benefit over placebo, predominantly for mood-related and overall PMS symptoms, though effects specifically on "Type C" symptoms (cravings and energy) are less well studied. Doses used in studies typically range from 50-100 mg/day. The use of B6 is not solely based on tradition; there is some scientific support, but the evidence is not strong or consistent, and optimal dosing and long-term safety are not fully established. Overall, the use of B6 for PMS, including "Type C," has limited scientific validation, with modest benefit in some women.

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