Vitamin B6 (pyridoxal 5'-phosphate) has some scientific basis for use in supporting or treating PMS Type C (the "cravings" type, characterized by symptoms such as carbohydrate cravings, increased appetite, headache, and fatigue). Several clinical studies and systematic reviews have explored the effects of vitamin B6 on premenstrual syndrome (PMS) symptoms in general, with some focusing on mood and somatic symptoms, but few have isolated Type C specifically. The rationale for B6 use is primarily linked to its role in neurotransmitter synthesis, particularly serotonin and dopamine, which influence mood and appetite regulation. A meta-analysis (Wyatt et al., 1999, BMJ) found that vitamin B6 may be more effective than placebo in relieving overall PMS symptoms, though study quality and effect sizes varied, and specific symptom clusters like cravings were not always separately analyzed. Doses up to 100 mg/day have been studied, with moderate improvements in symptoms such as irritability, fatigue, and carbohydrate cravings reported in some trials. However, the overall evidence is limited by methodological weaknesses and heterogeneity among studies. While vitamin B6 is commonly recommended in clinical practice for PMS, especially for mood and somatic symptoms, the evidence specific to PMS Type C is modest at best, justifying a low-to-moderate evidence rating.