Relationship: PMS Type C and vitamin B6

Evidence supporting the use of: Vitamin B6
For the health condition: PMS Type C

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Source of validity: Scientific
Rating (out of 5): 2

Vitamin B6 (pyridoxine) has been used to manage symptoms of premenstrual syndrome (PMS), particularly PMS Type C, which is characterized by carbohydrate craving, headaches, fatigue, and mood swings. The rationale for its use is based on its role in neurotransmitter synthesis, especially serotonin, which is thought to influence mood and cravings. Several clinical trials and reviews have investigated the efficacy of vitamin B6 in alleviating PMS symptoms. A 1999 meta-analysis published in the British Journal of Obstetrics and Gynaecology reviewed nine randomized controlled trials and found that vitamin B6 was more effective than placebo in reducing overall PMS symptoms, although the studies varied in quality and dosage. More recent Cochrane reviews suggest that while some benefit is evident, the evidence is limited by methodological flaws, small sample sizes, and inconsistent outcome measures. The typical effective dose in studies ranges from 50-100 mg daily; higher doses are not recommended due to risk of neuropathy. For PMS Type C specifically, which is thought to be linked to blood sugar fluctuations and neurotransmitter metabolism, vitamin B6 may help by modulating these pathways. However, the scientific evidence supporting its specific benefit for Type C PMS, as opposed to general PMS, is limited. In summary, there is some scientific support for vitamin B6 in PMS, but the quality and consistency of evidence rate it as modest (2/5).

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Evidence supporting the use of: Vitamin B6
For the health condition: PMS Type C

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Other ingredients used for PMS Type C

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Health concerns

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Evidence supporting the use of: Vitamin B6For the health condition: PMS Type C

Table of Contents

Synopsis

Other ingredients used for PMS Type C

Other health conditions supported by vitamin B6

Products containing vitamin B6

Evidence supporting the use of: Vitamin B6
For the health condition: PMS Type C