Evidence supporting the use of: Vitamin B6 (Mixed)
For the health condition: PMS Type A

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin B6 (pyridoxine) has been studied for its role in alleviating premenstrual syndrome (PMS), particularly PMS Type A, which is characterized by symptoms such as anxiety, irritability, and mood swings. The scientific basis for its use centers on vitamin B6's involvement in neurotransmitter synthesis, including serotonin and dopamine, which are implicated in mood regulation. Several randomized controlled trials and meta-analyses have evaluated the effectiveness of vitamin B6 supplementation for PMS symptoms. A 1999 meta-analysis published in the British Journal of Obstetrics and Gynaecology concluded that vitamin B6 is likely effective in reducing overall PMS symptoms, especially emotional symptoms, though the quality and size of the studies varied. Another systematic review in 2017 found that while vitamin B6 may be beneficial, the evidence is limited by methodological weaknesses and small sample sizes. Dosages in studies typically ranged from 50 to 100 mg per day.

Current clinical guidelines often mention vitamin B6 as a possible option for PMS symptom management, but they also note the need for larger, high-quality studies. Safety is generally good at recommended dosages, but high doses can cause neuropathy. In summary, there is moderate scientific evidence supporting the use of vitamin B6 for PMS Type A, mostly for mood-related symptoms, but further research is needed to confirm efficacy and establish optimal dosing.

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