Evidence supporting the use of: Pyridoxine alpha-ketoglutarate
For the health condition: PMS Type A

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Synopsis

Source of validity: Traditional
Rating (out of 5): 1

Pyridoxine alpha-ketoglutarate is a compound combining pyridoxine (vitamin B6) and alpha-ketoglutarate. Its use for PMS Type A (characterized by mood symptoms such as anxiety, irritability, and tension) is primarily based on tradition and extrapolation from the broader use of pyridoxine for premenstrual syndrome. Pyridoxine has a long-standing history in alternative and integrative medicine for alleviating PMS symptoms, with some studies suggesting modest benefits, particularly for mood-related symptoms. However, most research focuses on pyridoxine alone, not the alpha-ketoglutarate salt. The rationale for using the alpha-ketoglutarate form is typically to improve bioavailability or stability, but there is little to no direct scientific evidence that this combination is superior or specifically effective for PMS Type A. Clinical trials and reviews on vitamin B6 for PMS generally report small to moderate benefit, but authoritative bodies such as the Cochrane Database rate the quality of evidence as low to moderate, and no major guidelines specifically recommend the alpha-ketoglutarate form. Overall, the use of pyridoxine alpha-ketoglutarate for PMS Type A is rooted in traditional and empirical practice, not robust scientific validation.

More about Pyridoxine alpha-ketoglutarate
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Other health conditions supported by Pyridoxine alpha-ketoglutarate

PMS Type A

Products containing Pyridoxine alpha-ketoglutarate

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