Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B6 (pyridoxine hydrochloride) has been used to support or treat premenstrual syndrome (PMS) based on both some scientific evidence and traditional use, but primarily, its use is justified by limited scientific validation. Several randomized controlled trials and meta-analyses have evaluated the efficacy of vitamin B6 in reducing PMS symptoms, such as mood disturbances, irritability, and bloating. Some of these studies report modest improvements in overall symptoms compared to placebo, particularly for mood-related symptoms. A 1999 systematic review in the BMJ found weak evidence for the efficacy of vitamin B6, with methodological limitations in many included studies. Doses studied typically ranged from 50-100 mg per day. The biological rationale is that vitamin B6 is involved in neurotransmitter synthesis (such as serotonin and dopamine), which could theoretically impact mood and emotional symptoms associated with PMS. However, more recent reviews continue to conclude that while there may be a small benefit, the quality of the evidence is low, and larger, well-conducted trials are needed to confirm efficacy. Safety concerns with higher doses (such as neuropathy) also limit its use. In summary, while there is some scientific support for vitamin B6 in treating PMS, the evidence is weak to moderate, and its use remains somewhat controversial among experts.

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