Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B6 (Pyridoxine HCl) is used to support or treat premenstrual syndrome (PMS) based on some scientific evidence, though findings are mixed and the overall strength of evidence is considered low to moderate. Several randomized controlled trials and meta-analyses have investigated the effectiveness of vitamin B6 in reducing PMS symptoms such as mood swings, irritability, bloating, and breast tenderness. Some studies have found that daily doses of vitamin B6 (typically 50–100 mg) may provide modest relief for certain PMS symptoms, particularly in the realm of mood and affective symptoms. For example, a 1999 meta-analysis published in the British Journal of Obstetrics and Gynaecology concluded that vitamin B6 was more effective than placebo in alleviating overall PMS symptoms, with the greatest benefits seen in emotional symptoms.

However, study quality has often been low, with small sample sizes and methodological limitations. More recent reviews, including those by Cochrane, note that while there is some indication of benefit, the evidence is not robust and larger, high-quality studies are needed. Major health organizations do not universally recommend vitamin B6 for PMS, though it is sometimes used in clinical practice due to its relative safety at recommended dosages. In summary, the use of vitamin B6 for PMS is supported by some scientific evidence, but the effectiveness is not conclusively established.

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