Evidence supporting the use of: Vitamin B6 (Mixed)
For the health condition: PMS (general)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin B6 (pyridoxine) has been studied for its potential role in alleviating symptoms of premenstrual syndrome (PMS). Several clinical trials and systematic reviews have investigated its effects, particularly on mood-related symptoms such as irritability, depression, and fatigue. The proposed mechanism is that vitamin B6 acts as a cofactor in the synthesis of neurotransmitters like serotonin and dopamine, which may influence mood and emotional regulation during the menstrual cycle.

A 1999 systematic review in the British Journal of Obstetrics and Gynaecology analyzed nine trials and concluded that vitamin B6 may be beneficial for PMS, particularly for emotional symptoms, though study quality and sample sizes varied. A 2019 Cochrane review echoed these findings, suggesting a modest benefit with minimal side effects at recommended doses (typically up to 100 mg/day). However, the evidence is limited by methodological weaknesses, small sample sizes, and heterogeneity in diagnostic criteria and outcome measures.

Overall, while the scientific evidence is not robust, it does suggest a possible benefit of vitamin B6 supplementation for PMS, especially for mood and emotional symptoms. Most guidelines recommend considering it as an option, but not as a primary therapy. Larger, well-designed randomized controlled trials are needed for more definitive conclusions.

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Products containing Vitamin B6 (Mixed)

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